| E 350 CDI BlueEFFICIENCY V6 (265 CH) 4MATIC 7G-TRONIC PLUS | 194 kW (265 ch) | 173–175 g/km | 2987 cc | Diesel | | Euro 5 |
| E 350 CDI BlueEFFICIENCY V6 (265 CH) 7G-TRONIC PLUS | 194 kW (265 ch) | 153–159 g/km | 2987 cc | Diesel | | Euro 5 |
| E 350 CDI BlueEFFICIENCY V6 (231 CH) 7G-TRONIC | 169 kW (231 ch) | 179–186 g/km | 2987 cc | Diesel | | Euro 5 |
| E 350 CDI BlueEFFICIENCY V6 (231 CH) 4MATIC 7G-TRONIC | 169 kW (231 ch) | 183–188 g/km | 2987 cc | Diesel | | Euro 5 |
| E 300 CDI BlueEFFICIENCY V6 (231 CH) 7G-TRONIC PLUS | 169 kW (231 ch) | 153–159 g/km | 2987 cc | Diesel | | Euro 5 |
| E 350 BlueTEC V6 (211 CH) 7G-TRONIC PLUS | 155 kW (211 ch) | 180–188 g/km | 2987 cc | Diesel | | Euro 6 |
| E 250 CDI BlueEFFICIENCY (204 CH) | 150 kW (204 ch) | 139–144 g/km | 2143 cc | Diesel | | Euro 5 |
| E 250 CDI BlueEFFICIENCY (204 CH) 5G-TRONIC | 150 kW (204 ch) | 154–159 g/km | 2143 cc | Diesel | | Euro 5 |
| E 300 CDI BlueEFFICIENCY V6 (204 CH) 7G-TRONIC | 150 kW (204 ch) | 179–186 g/km | 2987 cc | Diesel | | Euro 5 |
| E 250 CDI BlueEFFICIENCY (204 CH) 7G-TRONIC PLUS | 150 kW (204 ch) | 129–138 g/km | 2143 cc | Diesel | | Euro 5 |
| E 250 CDI BlueEFFICIENCY (204 CH) 4MATIC 7G-TRONIC PLUS | 150 kW (204 ch) | 147–152 g/km | 2143 cc | Diesel | | Euro 5 |
| E 250 CDI BlueEFFICIENCY (204 CH) Start & Stop | 150 kW (204 ch) | 130–139 g/km | 2143 cc | Diesel | | Euro 5 |
| E 250 CDI BlueEFFICIENCY (204 CH) 4MATIC 7G-TRONIC | 150 kW (204 ch) | 164–176 g/km | 2143 cc | Diesel | | Euro 5 |
| E 300 BlueTEC Hybrid (204 CH) 7G-TRONIC PLUS | 150 kW (204 ch) | 109–112 g/km | 2143 cc | Diesel | | Euro 5 |
| E 220 CDI BlueEFFICIENCY (170 CH) | 125 kW (170 ch) | 139–144 g/km | 2143 cc | Diesel | | Euro 5 |
| E 220 CDI BlueEFFICIENCY (170 CH) 5G-TRONIC | 125 kW (170 ch) | 154–169 g/km | 2143 cc | Diesel | | Euro 5 |
| E 220 CDI BlueEFFICIENCY (170 CH) 7G-TRONIC PLUS | 125 kW (170 ch) | 129–138 g/km | 2143 cc | Diesel | | Euro 5 |
| E 220 CDI BlueEFFICIENCY (170 CH) Start & Stop | 125 kW (170 ch) | 130–139 g/km | 2143 cc | Diesel | | Euro 5 |
| E 220 CDI BlueEFFICIENCY Edition (170 CH) | 125 kW (170 ch) | 119 g/km | 2143 cc | Diesel | | Euro 5 |
| E 200 CDI BlueEFFICIENCY (136 CH) | 100 kW (136 ch) | 137–145 g/km | 2143 cc | Diesel | | Euro 5 |
| E 200 CDI BlueEFFICIENCY (136 CH) 5G-TRONIC | 100 kW (136 ch) | 145–153 g/km | 2143 cc | Diesel | | Euro 5 |
| E 200 CDI BlueEFFICIENCY (136 CH) 7G-TRONIC PLUS | 100 kW (136 ch) | 134–141 g/km | 2143 cc | Diesel | | Euro 5 |
| E 200 CDI BlueEFFICIENCY (136 CH) Start & Stop | 100 kW (136 ch) | 134–141 g/km | 2143 cc | Diesel | | Euro 5 |
| AMG E 63 V8 (525 CH) AMG SPEEDSHIFT MCT | 386 kW (525 ch) | 295 g/km | 6208 cc | Benzin | | Euro 5 |
| AMG E 63 V8 BITURBO (525 CH) AMG SPEEDSHIFT MCT | 386 kW (525 ch) | 230 g/km | 5461 cc | Benzin | | Euro 5 |
| E 500 BlueEFFICIENCY V8 (408 CH) 4MATIC 7G-TRONIC PLUS | 300 kW (408 ch) | 219 g/km | 4663 cc | Benzin | | Euro 5 |
| E 500 BlueEFFICIENCY V8 (408 CH) 7G-TRONIC PLUS | 300 kW (408 ch) | 209 g/km | 4663 cc | Benzin | | Euro 5 |
| E 500 V8 (388 CH) 7G-TRONIC | 285 kW (388 ch) | 253–261 g/km | 5461 cc | Benzin | | Euro 5 |
| E 500 V8 (388 CH) 4MATIC 7G-TRONIC | 285 kW (388 ch) | 258–264 g/km | 5461 cc | Benzin | | Euro 5 |
| E 550 V8 (382 CH) 4MATIC 7G-TRONIC | 281 kW (382 ch) | — | 5461 cc | Benzin | | — |
| E 550 V8 (382 CH) 7G-TRONIC | 281 kW (382 ch) | — | 5461 cc | Benzin | | — |
| E 400 V6 (329 CH) Hybrid 7G-TRONIC PLUS | 242 kW (329 ch) | — | 3498 cc | Benzin | | — |
| E 350 BlueEFFICIENCY V6 (306 CH) 4MATIC 7G-TRONIC PLUS | 225 kW (306 ch) | 174–176 g/km | 3498 cc | Benzin | | Euro 5 |
| E 350 BlueEFFICIENCY V6 (306 CH) 7G-TRONIC PLUS | 225 kW (306 ch) | 159–164 g/km | 3498 cc | Benzin | | Euro 5 |
| E 350 BlueEFFICIENCY V6 (292 CH) 7G-TRONIC | 214 kW (292 ch) | 199–205 g/km | 3489 cc | Benzin | | Euro 5 |
| E 350 V6 (272 CH) 4MATIC 7G-TRONIC | 200 kW (272 ch) | 226–229 g/km | 3498 cc | Benzin | | Euro 5 |
| E 350 V6 (268 CH) 7G-TRONIC | 197 kW (268 ch) | — | 3498 cc | Benzin | | — |
| E 300 BlueEFFICIENCY V6 (252 CH) 7G-TRONIC PLUS | 185 kW (252 ch) | 159–164 g/km | 3498 cc | Benzin | | Euro 5 |
| E 300 BlueEFFICIENCY V6 (252 CH) 4MATIC 7G-TRONIC PLUS | 185 kW (252 ch) | 174–176 g/km | 3498 cc | Benzin | | Euro 5 |
| E 300 V6 (231 CH) 7G-TRONIC | 169 kW (231 ch) | — | 2996 cc | Benzin | | — |
| E 250 CGI BlueEFFICIENCY (204 CH) 5G-TRONIC | 150 kW (204 ch) | 179–187 g/km | 1796 cc | Benzin | | Euro 5 |
| E 250 BlueEFFICIENCY (204 CH) 7G-TRONIC PLUS | 150 kW (204 ch) | 154–162 g/km | 1796 cc | Benzin | | Euro 5 |
| E 200 CGI BlueEFFICIENCY (184 CH) | 135 kW (184 ch) | 169–176 g/km | 1796 cc | Benzin | | Euro 5 |
| E 200 CGI BlueEFFICIENCY (184 CH) 5G-TRONIC | 135 kW (184 ch) | 177–184 g/km | 1796 cc | Benzin | | Euro 5 |
| E 200 BlueEFFICIENCY (184 CH) 7G-TRONIC PLUS | 135 kW (184 ch) | 152–160 g/km | 1796 cc | Benzin | | Euro 5 |
| E 200 NGT BlueEFFICIENCY (163 CH) 5G-TRONIC | 119 kW (163 ch) | 149–155 g/km | 1796 cc | Benzin | | Euro 5 |