| E 350 BlueTEC V6 (258 CH) 9G-TRONIC | 189 kW (258 ch) | 133–139 g/km | 2987 cc | Diesel | | Euro 6 |
| E 350 BlueTEC V6 (258 CH) 4MATIC 9G-TRONIC | 189 kW (258 ch) | 150–156 g/km | 2987 cc | Diesel | | Euro 6 |
| E 350 BlueTEC V6 (252 CH) 9G-TRONIC | 185 kW (252 ch) | 138–148 g/km | 2987 cc | Diesel | | Euro 6 |
| E 350 BlueTEC V6 (252 CH) 4MATIC 7G-TRONIC PLUS | 185 kW (252 ch) | 159–164 g/km | 2987 cc | Diesel | | Euro 6 |
| E 300 BlueTEC V6 (231 CH) 7G-TRONIC PLUS | 169 kW (231 ch) | 144–154 g/km | 2987 cc | Diesel | | Euro 6 |
| E 300 BlueTEC V6 (231 CH) 9G-TRONIC | 169 kW (231 ch) | 133–139 g/km | 2987 cc | Diesel | | Euro 6 |
| E 250 CDI (204 CH) | 150 kW (204 ch) | 126–132 g/km | 2143 cc | Diesel | | Euro 5 |
| E 250 CDI (204 CH) 4MATIC 7G-TRONIC PLUS | 150 kW (204 ch) | 140–149 g/km | 2143 cc | Diesel | | Euro 5 |
| E 300 BlueTEC (204 CH) HYBRID 7G-TRONIC PLUS | 150 kW (204 ch) | 99–110 g/km | 2143 cc | Diesel | | Euro 5 |
| E 250 CDI (204 CH) 7G-TRONIC PLUS | 150 kW (204 ch) | 126–134 g/km | 2143 cc | Diesel | | Euro 5 |
| E 250 BlueTEC (204 CH) 4MATIC 7G-TRONIC PLUS | 150 kW (204 ch) | 135–139 g/km | 2143 cc | Diesel | | Euro 6 |
| E 250 BlueTEC (204 CH) | 150 kW (204 ch) | 121–130 g/km | 2143 cc | Diesel | | Euro 6 |
| E 250 BlueTEC (204 CH) 9G-TRONIC | 150 kW (204 ch) | 116–123 g/km | 2143 cc | Diesel | | Euro 6 |
| E 220 CDI (170 CH) | 125 kW (170 ch) | 123–129 g/km | 2143 cc | Diesel | | Euro 5 |
| E 220 CDI (170 CH) 7G-TRONIC PLUS | 125 kW (170 ch) | 123–131 g/km | 2143 cc | Diesel | | Euro 5 |
| E 220 BlueTEC (170 CH) 9G-TRONIC | 125 kW (170 ch) | 116–123 g/km | 2143 cc | Diesel | | Euro 6 |
| E 220 BlueTEC (170 CH) | 125 kW (170 ch) | 118–127 g/km | 2143 cc | Diesel | | Euro 6 |
| E 220 BlueTEC (170 CH) 4MATIC 7G-TRONIC PLUS | 125 kW (170 ch) | 135–139 g/km | 2143 cc | Diesel | | Euro 6 |
| E 200 CDI (136 CH) | 100 kW (136 ch) | 125–134 g/km | 2143 cc | Diesel | | Euro 5 |
| E 200 CDI (136 CH) 7G-TRONIC PLUS | 100 kW (136 ch) | 127–135 g/km | 2143 cc | Diesel | | Euro 5 |
| E 200 BlueTEC (136 CH) 7G-TRONIC PLUS | 100 kW (136 ch) | 119–128 g/km | 2143 cc | Diesel | | Euro 6 |
| E 200 BlueTEC (136 CH) | 100 kW (136 ch) | 119–125 g/km | 2143 cc | Diesel | | Euro 6 |
| AMG E 63 S V8 (585 CH) 4MATIC AMG SPEEDSHIFT MCT | 430 kW (585 ch) | 242 g/km | 5461 cc | Benzin | | Euro 6 |
| AMG E 63 V8 (557 CH) 4MATIC AMG SPEEDSHIFT MCT | 409 kW (557 ch) | 242 g/km | 5461 cc | Benzin | | Euro 6 |
| AMG E 63 V8 (557 CH) AMG SPEEDSHIFT MCT | 409 kW (557 ch) | 230 g/km | 5461 cc | Benzin | | Euro 6 |
| E 500 V8 (408 CH) 4MATIC 7G-TRONIC PLUS | 300 kW (408 ch) | 219 g/km | 4663 cc | Benzin | | Euro 5 |
| E 500 V8 (408 CH) 7G-TRONIC PLUS | 300 kW (408 ch) | 209 g/km | 4663 cc | Benzin | | Euro 5 |
| E 500 V8 (408 CH) 7G-TRONIC PLUS | 300 kW (408 ch) | 207–208 g/km | 4663 cc | Benzin | | Euro 6 |
| E 500 V8 (408 CH) 4MATIC 7G-TRONIC PLUS | 300 kW (408 ch) | 219–222 g/km | 4663 cc | Benzin | | Euro 6 |
| E 400 V6 3.0 (333 CH) 4MATIC 7G-TRONIC PLUS | 244 kW (333 ch) | 189–199 g/km | 2996 cc | Benzin | | Euro 6 |
| E 400 V6 3.0 (333 CH) 7G-TRONIC PLUS | 244 kW (333 ch) | 175–185 g/km | 2996 cc | Benzin | | Euro 6 |
| E 400 V6 3.5 (333 CH) 7G-TRONIC PLUS | 244 kW (333 ch) | 160–165 g/km | 3498 cc | Benzin | | Euro 6 |
| E 400 V6 3.5 (333 CH) 4MATIC 7G-TRONIC PLUS | 244 kW (333 ch) | 172–179 g/km | 3498 cc | Benzin | | Euro 6 |
| E 400 V6 (329 CH) Hybrid 7G-TRONIC PLUS | 242 kW (329 ch) | — | 3498 cc | Benzin | | PZEV |
| E 350 V6 (306 CH) 4MATIC 7G-TRONIC PLUS | 225 kW (306 ch) | 174–176 g/km | 3498 cc | Benzin | | Euro 5 |
| E 350 V6 (306 CH) 7G-TRONIC PLUS | 225 kW (306 ch) | 159–164 g/km | 3498 cc | Benzin | | Euro 5 |
| E 300 V6 (252 CH) 7G-TRONIC PLUS | 185 kW (252 ch) | 159–164 g/km | 3498 cc | Benzin | | Euro 5 |
| E 300 V6 (252 CH) 4MATIC 7G-TRONIC PLUS | 185 kW (252 ch) | 174–176 g/km | 3498 cc | Benzin | | Euro 5 |
| E 250 (211 CH) 7G-TRONIC PLUS | 155 kW (211 ch) | 135–142 g/km | 1991 cc | Benzin | | Euro 6 |
| E 200 (184 CH) | 135 kW (184 ch) | 142–151 g/km | 1991 cc | Benzin | | Euro 6 |
| E 200 (184 CH) 7G-TRONIC PLUS | 135 kW (184 ch) | 135–142 g/km | 1991 cc | Benzin | | Euro 6 |
| E 200 Natural Gas Drive (156 CH) 7G-TRONIC PLUS | 114 kW (156 ch) | 116–120 g/km | 1991 cc | Benzin | | Euro 6 |
| E 180 (156 CH) 7G-TRONIC PLUS | 114 kW (156 ch) | — | 1595 cc | Benzin | | Euro 6 |