| E 400d (340 CH) 4MATIC 9G-TRONIC | 250 kW (340 ch) | 191–204 g/km | 2925 cc | Diesel | 9 versnellingen Automatisch | Euro 6 |
| E 350d (258 CH) 9G-TRONIC | 189 kW (258 ch) | — | 2987 cc | Diesel | 9 versnellingen Automatisch | Euro 6 |
| E 350d (258 CH) 4MATIC 9G-TRONIC | 189 kW (258 ch) | — | 2987 cc | Diesel | 9 versnellingen Automatisch | Euro 6 |
| E 300d (245 CH) 9G-TRONIC | 180 kW (245 ch) | 159–184 g/km | 1950 cc | Diesel | 9 versnellingen Automatisch | Euro 6d-TEMP-EVAP-ISC |
| E 220d (194 CH) 9G-TRONIC | 142 kW (194 ch) | 148–176 g/km | 1950 cc | Diesel | 9 versnellingen Automatisch | Euro 6 |
| E 220d (194 CH) 4MATIC 9G-TRONIC | 142 kW (194 ch) | 173–190 g/km | 1950 cc | Diesel | 9 versnellingen Automatisch | Euro 6 |
| E 200d (160 CH) 9G-TRONIC | 117 kW (160 ch) | 148 g/km | 1598 cc | Diesel | 9 versnellingen Automatisch | Euro 6d-TEMP-EVAP-ISC |
| E 200d (150 CH) 9G-TRONIC | 110 kW (150 ch) | 141–168 g/km | 1950 cc | Diesel | 9 versnellingen Automatisch | Euro 6 |
| AMG E 63 S V8 (612 CH) 4MATIC+ MCT | 450 kW (612 ch) | 274–283 g/km | 3982 cc | Benzine | 9 versnellingen Automatisch | Euro 6 |
| AMG E 63 V8 (571 CH) 4MATIC+ MCT | 420 kW (571 ch) | 274–283 g/km | 3982 cc | Benzine | 9 versnellingen Automatisch | Euro 6 |
| AMG E 53 (435 CH) EQ Boost 4MATIC+ AMG SPEEDSHIFT TCT | 319 kW (435 ch) | 208–218 g/km | 2999 cc | Benzine | 9 versnellingen Automatisch | Euro 6 |
| AMG E 43 (401 CH) 4MATIC 9G-TRONIC | 294 kW (401 ch) | — | 2996 cc | Benzine | 9 versnellingen Automatisch | Euro 6 |
| E 450 V6 (367 CH) 4MATIC 9G-TRONIC | 269 kW (367 ch) | 206–227 g/km | 2996 cc | Benzine | 9 versnellingen Automatisch | Euro 6d-TEMP-EVAP-ISC |
| E 400 V6 3.5 (333 CH) 4MATIC 9G-TRONIC | 244 kW (333 ch) | 180–186 g/km | 3498 cc | Benzine | 9 versnellingen Automatisch | Euro 6 |
| E 400 V6 3.0 (329 CH) 4MATIC 9G-TRONIC | 242 kW (329 ch) | — | 2996 cc | Benzine | 9 versnellingen Automatisch | — |
| E 300 (258 CH) EQ Boost 9G-TRONIC | 189 kW (258 ch) | 167–194 g/km | 1991 cc | Benzine | 9 versnellingen Automatisch | Euro 6d-TEMP-EVAP-ISC |
| E 250 (211 CH) 9G-TRONIC | 155 kW (211 ch) | — | 1991 cc | Benzine | 9 versnellingen Automatisch | Euro 6 |
| E 200 (197 CH) EQ Boost 9G-TRONIC | 144 kW (197 ch) | 165–191 g/km | 1991 cc | Benzine | 9 versnellingen Automatisch | Euro 6d-TEMP-EVAP-ISC |
| E 200 (197 CH) EQ Boost 4MATIC 9G-TRONIC | 144 kW (197 ch) | 174–201 g/km | 1991 cc | Benzine | 9 versnellingen Automatisch | Euro 6d-TEMP-EVAP-ISC |
| E 200 (184 CH) 9G-TRONIC | 135 kW (184 ch) | — | 1991 cc | Benzine | 9 versnellingen Automatisch | Euro 6 |
| E 200 (184 CH) 4MATIC 9G-TRONIC | 135 kW (184 ch) | — | 1991 cc | Benzine | 9 versnellingen Automatisch | Euro 6 |
| E 300de (306 CH) Plug-In Hybrid 9G-TRONIC | 225 kW (306 ch) | 38–43 g/km | 1950 cc | Hybride | 9 versnellingen Automatisch | Euro 6 |