| E 400d (330 CH) 4MATIC 9G-TRONIC | 242 kW (330 ch) | — | 2925 cc | Diesel | 9 versnellingen Automatisch | EURO 6d-ISC-FCM |
| E 300d (265 CH) EQ Boost 4MATIC 9G-TRONIC | 194 kW (265 ch) | 147–156 g/km | 1992 cc | Diesel | 9 versnellingen Automatisch | Euro 6D-ISC-FCM |
| E 220d (200 CH) EQ Boost 9G-TRONIC | 147 kW (200 ch) | 132–150 g/km | 1993 cc | Diesel | 9 versnellingen Automatisch | Euro 6d-ISC-FCM |
| E 220d (200 CH) EQ Boost 4MATIC 9G-TRONIC | 147 kW (200 ch) | 141–160 g/km | 1993 cc | Diesel | 9 versnellingen Automatisch | Euro 6d-ISC-FCM |
| E 220d (194 CH) 9G-TRONIC | 142 kW (194 ch) | — | 1950 cc | Diesel | 9 versnellingen Automatisch | EURO 6d-ISC-FCM |
| E 220d (194 CH) 4MATIC 9G-TRONIC | 142 kW (194 ch) | — | 1950 cc | Diesel | 9 versnellingen Automatisch | EURO 6d-ISC-FCM |
| E 200d (160 CH) 9G-TRONIC | 117 kW (160 ch) | — | 1598 cc | Diesel | 9 versnellingen Automatisch | EURO 6d-ISC-FCM |
| AMG E 63 S (612 CH) 4MATIC+ MCT | 450 kW (612 ch) | — | 3982 cc | Benzine | 9 versnellingen Automatisch | EURO 6d-ISC-FCM |
| AMG E 53 (435 CH) EQ Boost 4MATIC+ TCT | 319 kW (435 ch) | — | 2999 cc | Benzine | 9 versnellingen Automatisch | EURO 6d-ISC-FCM |
| E 450 (367 CH) EQ Boost 4MATIC 9G-TRONIC | 269 kW (367 ch) | — | 2999 cc | Benzine | 9 versnellingen Automatisch | EURO 6d-ISC-FCM |
| E 300 (258 CH) EQ Boost 9G-TRONIC | 189 kW (258 ch) | — | 1991 cc | Benzine | 9 versnellingen Automatisch | EURO 6d-ISC-FCM |
| E 200 (197 CH) EQ Boost 9G-TRONIC | 144 kW (197 ch) | — | 1991 cc | Benzine | 9 versnellingen Automatisch | EURO 6d-ISC-FCM |
| E 200 (197 CH) EQ Boost 4MATIC 9G-TRONIC | 144 kW (197 ch) | — | 1991 cc | Benzine | 9 versnellingen Automatisch | EURO 6d-ISC-FCM |
| E 300e (320 CH) Plug-in Hybrid 9G-TRONIC | 235 kW (320 ch) | 38–42 g/km | 1991 cc | Hybride | 9 versnellingen Automatisch | EURO 6d-ISC-FCM |
| E 300de (306 CH) Plug-in Hybrid 9G-TRONIC | 225 kW (306 ch) | 35–45 g/km | 1950 cc | Hybride | 9 versnellingen Automatisch | EURO 6d-ISC-FCM |
| E 300de (306 CH) Plug-in Hybrid 4MATIC 9G-TRONIC | 225 kW (306 ch) | 36–42 g/km | 1950 cc | Hybride | 9 versnellingen Automatisch | EURO 6d-ISC-FCM |