| E 420 CDI V8 (314 CH) 7G-TRONIC | 230 kW (314 ch) | 246 g/km | 3996 cc | Diesel | 7 versnellingen Automatisch | Euro 4 |
| E 320 CDI V6 (224 CH) 7G-TRONIC | 164 kW (224 ch) | 194–202 g/km | 2987 cc | Diesel | 7 versnellingen Automatisch | Euro 4 |
| E 320 CDI V6 (224 CH) 4MATIC 5G-TRONIC | 164 kW (224 ch) | 210–215 g/km | 2987 cc | Diesel | 5 versnellingen Automatisch | Euro 4 |
| E 300 BLUETEC V6 (211 CH) 7G-TRONIC | 155 kW (211 ch) | 189–199 g/km | 2987 cc | Diesel | 7 versnellingen Automatisch | Euro 4 |
| E 320 BLUETEC (208 CH) 7G-TRONIC | 153 kW (208 ch) | — | 2987 cc | Diesel | 7 versnellingen Automatisch | — |
| E 280 CDI V6 (190 CH) 4MATIC 5G-TRONIC | 139 kW (190 ch) | 207–212 g/km | 2987 cc | Diesel | 5 versnellingen Automatisch | Euro 4 |
| E 280 CDI V6 (190 CH) 7G-TRONIC | 139 kW (190 ch) | 191–199 g/km | 2987 cc | Diesel | 7 versnellingen Automatisch | Euro 4 |
| E 280 CDI V6 (190 CH) | 139 kW (190 ch) | 183–189 g/km | 2987 cc | Diesel | 6 versnellingen Handgeschakeld | Euro 4 |
| E 220 CDI (170 CH) | 125 kW (170 ch) | 160–168 g/km | 2148 cc | Diesel | 6 versnellingen Handgeschakeld | Euro 4 |
| E 220 CDI (170 CH) 5G-TRONIC | 125 kW (170 ch) | 184–187 g/km | 2148 cc | Diesel | 5 versnellingen Automatisch | Euro 4 |
| E 200 CDI (136 CH) | 100 kW (136 ch) | 160–168 g/km | 2148 cc | Diesel | 6 versnellingen Handgeschakeld | Euro 4 |
| E 200 CDI (136 CH) 5G-TRONIC | 100 kW (136 ch) | 173–186 g/km | 2148 cc | Diesel | 5 versnellingen Automatisch | Euro 4 |
| AMG E 63 V8 (514 CH) 7G-TRONIC | 378 kW (514 ch) | 341 g/km | 6208 cc | Benzine | 7 versnellingen Automatisch | Euro 4 |
| E 500 V8 (388 CH) 7G-TRONIC | 285 kW (388 ch) | 273 g/km | 5461 cc | Benzine | 7 versnellingen Automatisch | Euro 4 |
| E 500 V8 (388 CH) 4MATIC 5G-TRONIC | 285 kW (388 ch) | 293 g/km | 5461 cc | Benzine | 5 versnellingen Automatisch | Euro 4 |
| E 550 V8 (382 CH) 7G-TRONIC | 281 kW (382 ch) | — | 5461 cc | Benzine | 7 versnellingen Automatisch | — |
| E 550 V8 (382 CH) 5G-TRONIC 4MATIC | 281 kW (382 ch) | — | 5461 cc | Benzine | 5 versnellingen Automatisch | — |
| E 350 CGI (292 CH) 7G-TRONIC | 214 kW (292 ch) | — | 3498 cc | Benzine | 7 versnellingen Automatisch | — |
| E 350 V6 (272 CH) 4MATIC 5G-TRONIC | 200 kW (272 ch) | 247–255 g/km | 3498 cc | Benzine | 5 versnellingen Automatisch | Euro 4 |
| E 350 V6 (272 CH) 7G-TRONIC | 200 kW (272 ch) | 231–244 g/km | 3498 cc | Benzine | 7 versnellingen Automatisch | Euro 4 |
| E 280 V6 (231 CH) | 169 kW (231 ch) | 222–227 g/km | 2996 cc | Benzine | 6 versnellingen Handgeschakeld | Euro 4 |
| E 280 V6 (231 CH) 7G-TRONIC | 169 kW (231 ch) | 224–232 g/km | 2996 cc | Benzine | 7 versnellingen Automatisch | Euro 4 |
| E 280 V6 (231 CH) 4MATIC 5G-TRONIC | 169 kW (231 ch) | 237–245 g/km | 2996 cc | Benzine | 5 versnellingen Automatisch | Euro 4 |
| E 230 V6 (204 CH) | 150 kW (204 ch) | 220–223 g/km | 2496 cc | Benzine | 6 versnellingen Handgeschakeld | Euro 4 |
| E 230 V6 (204 CH) 7G-TRONIC | 150 kW (204 ch) | 225–230 g/km | 2496 cc | Benzine | 7 versnellingen Automatisch | Euro 4 |
| E 200 Kompressor (184 CH) | 135 kW (184 ch) | 195–210 g/km | 1796 cc | Benzine | 6 versnellingen Handgeschakeld | Euro 4 |
| E 200 Kompressor (184 CH) 5G-TRONIC | 135 kW (184 ch) | 202–212 g/km | 1796 cc | Benzine | 5 versnellingen Automatisch | Euro 4 |
| E 200 NGT (163 CH) 5G-TRONIC | 119 kW (163 ch) | — | 1796 cc | Benzine | 5 versnellingen Automatisch | — |