| ML 420 CDI V8 (306 CH) 4MATIC 7G-TRONIC | 225 kW (306 ch) | 279–292 g/km | 3996 cc | Diesel | 7 versnellingen Automatisch | Euro 4 |
| ML 450 CDI V8 (306 CH) 4MATIC 7G-TRONIC | 225 kW (306 ch) | 279–292 g/km | 3996 cc | Diesel | 7 versnellingen Automatisch | Euro 4 |
| ML 350 CDI V6 (231 CH) 4MATIC 7G-TRONIC | 169 kW (231 ch) | 235–246 g/km | 2987 cc | Diesel | 7 versnellingen Automatisch | Euro 5 |
| ML 320 CDI V6 (224 CH) 4MATIC 7G-TRONIC | 164 kW (224 ch) | 245–254 g/km | 2987 cc | Diesel | 7 versnellingen Automatisch | Euro 4 |
| ML 350 CDI V6 (224 CH) 4MATIC 7G-TRONIC | 164 kW (224 ch) | 235–250 g/km | 2987 cc | Diesel | 7 versnellingen Automatisch | Euro 4 |
| ML 350 BlueTEC V6 (211 CH) 4MATIC 7G-TRONIC | 155 kW (211 ch) | 231–239 g/km | 2987 cc | Diesel | 7 versnellingen Automatisch | Euro 6 |
| ML 300 CDI BlueEFFICIENCY V6 (204 CH) 4MATIC 7G-TRONIC | 150 kW (204 ch) | 224–240 g/km | 2987 cc | Diesel | 7 versnellingen Automatisch | Euro 5 |
| ML 280 CDI V6 (190 CH) 4MATIC 7G-TRONIC | 139 kW (190 ch) | 241–254 g/km | 2987 cc | Diesel | 7 versnellingen Automatisch | Euro 4 |
| ML 300 CDI BlueEFFICIENCY V6 (190 CH) 4MATIC 7G-TRONIC | 139 kW (190 ch) | 222–246 g/km | 2987 cc | Diesel | 7 versnellingen Automatisch | Euro 4 |
| AMG ML 63 V8 (510 CH) 4MATIC 7G-TRONIC AMG SPEEDSHIFT | 375 kW (510 ch) | 392 g/km | 6208 cc | Benzine | 7 versnellingen Automatisch | Euro 4 |
| ML 500 V8 (388 CH) 4MATIC 7G-TRONIC | 285 kW (388 ch) | 304 g/km | 5461 cc | Benzine | 7 versnellingen Automatisch | Euro 4 |
| ML 500 V8 (388 CH) 4MATIC 7G-TRONIC | 285 kW (388 ch) | 304 g/km | 5461 cc | Benzine | 7 versnellingen Automatisch | Euro 5 |
| ML 450 HYBRID V6 (340 CH) 4MATIC CVT | 250 kW (340 ch) | — | 3498 cc | Benzine | | SULEV |
| ML 350 V6 (272 CH) 4MATIC 7G-TRONIC | 200 kW (272 ch) | 266–281 g/km | 3498 cc | Benzine | 7 versnellingen Automatisch | Euro 4 |
| ML 350 V6 (272 CH) 4MATIC 7G-TRONIC | 200 kW (272 ch) | 266–281 g/km | 3498 cc | Benzine | 7 versnellingen Automatisch | Euro 5 |