| S 450 CDI V8 (320 CH) G-TRONIC | 235 kW (320 ch) | — | 3996 cc | Diesel | 7 versnellingen Automatisch | — |
| S 350 CDI BlueTEC (258 CH) 4MATIC G-TRONIC | 189 kW (258 ch) | — | 2987 cc | Diesel | 7 versnellingen Automatisch | Euro 6 |
| S 350 CDI BlueTEC (258 CH) G-TRONIC | 189 kW (258 ch) | — | 2987 cc | Diesel | 7 versnellingen Automatisch | Euro 6 |
| S 350 CDI BlueEFFICIENCY (235 CH) G-TRONIC | 172 kW (235 ch) | — | 2987 cc | Diesel | 7 versnellingen Automatisch | — |
| S 350 CDI BlueEFFICIENCY (235 CH) 4MATIC G-TRONIC | 172 kW (235 ch) | — | 2987 cc | Diesel | 7 versnellingen Automatisch | — |
| S 250 CDI BlueEFFICIENCY (204 CH) 7G-TRONIC PLUS | 150 kW (204 ch) | 149–151 g/km | 2143 cc | Diesel | 7 versnellingen Automatisch | Euro 5 |
| AMG S 65 V12 (630 CH) Automatic | 463 kW (630 ch) | — | 5980 cc | Benzine | 5 versnellingen Automatisch | Euro 5 |
| AMG S 65 V12 (612 CH) Automatic | 450 kW (612 ch) | — | 5980 cc | Benzine | 5 versnellingen Automatisch | Euro 5 |
| AMG S 63 V8 (544 CH) AMG SPEEDSHIFT MCT | 400 kW (544 ch) | 244 g/km | 5461 cc | Benzine | 7 versnellingen Automatisch | Euro 5 |
| AMG S 63 V8 (525 CH) AMG SPEEDSHIFT 7G-TRONIC | 386 kW (525 ch) | 347 g/km | 6208 cc | Benzine | 7 versnellingen Automatisch | Euro 4 |
| S 600 V12 (517 CH) Automatic | 380 kW (517 ch) | — | 5513 cc | Benzine | 5 versnellingen Automatisch | Euro 5 |
| S 500 BlueEFFICIENCY (435 CH) 4MATIC G-TRONIC | 319 kW (435 ch) | — | 4663 cc | Benzine | 7 versnellingen Automatisch | Euro 5 |
| S 500 BlueEFFICIENCY V8 (435 CH) G-TRONIC | 319 kW (435 ch) | — | 4663 cc | Benzine | 7 versnellingen Automatisch | Euro 5 |
| S 500 V8 (388 CH) 4MATIC G-TRONIC | 285 kW (388 ch) | — | 5461 cc | Benzine | 7 versnellingen Automatisch | — |
| S 500 V8 (388 CH) G-TRONIC | 285 kW (388 ch) | — | 5461 cc | Benzine | 7 versnellingen Automatisch | — |
| S 450 V8 (340 CH) 4MATIC G-TRONIC | 250 kW (340 ch) | — | 4663 cc | Benzine | 7 versnellingen Automatisch | — |
| S 450 V8 (340 CH) G-TRONIC | 250 kW (340 ch) | — | 4663 cc | Benzine | 7 versnellingen Automatisch | — |
| S 350 BlueEFFICIENCY (306 CH) 4MATIC G-TRONIC | 225 kW (306 ch) | — | 3498 cc | Benzine | 7 versnellingen Automatisch | Euro 5 |
| S 350 BlueEFFICIENCY (306 CH) G-TRONIC | 225 kW (306 ch) | — | 3498 cc | Benzine | 7 versnellingen Automatisch | Euro 5 |
| S 400 V6 (299 CH) HYBRID 7G-TRONIC | 219 kW (299 ch) | 188–191 g/km | 3498 cc | Benzine | 7 versnellingen Automatisch | Euro 5 |
| S 350 (272 CH) 4MATIC G-TRONIC | 200 kW (272 ch) | — | 3498 cc | Benzine | 7 versnellingen Automatisch | — |
| S 350 (272 CH) G-TRONIC | 200 kW (272 ch) | — | 3498 cc | Benzine | 7 versnellingen Automatisch | — |