| S 350 BlueTEC V6 (258 CH) 7G-TRONIC PLUS | 189 kW (258 ch) | 148–158 g/km | 2987 cc | Diesel | 7 versnellingen Automatisch | Euro 6 |
| S 350 BlueTEC V6 (258 CH) 4MATIC 7G-TRONIC PLUS | 189 kW (258 ch) | 156–168 g/km | 2987 cc | Diesel | 7 versnellingen Automatisch | Euro 6 |
| S 350d V6 (258 CH) 9G-TRONIC | 189 kW (258 ch) | 141–157 g/km | 2987 cc | Diesel | 9 versnellingen Automatisch | Euro 6 |
| S 350d V6 (258 CH) 4MATIC 9G-TRONIC | 189 kW (258 ch) | 149–169 g/km | 2987 cc | Diesel | 9 versnellingen Automatisch | Euro 6 |
| S 300 BlueTEC (231 CH) HYBRID G-TRONIC | 169 kW (231 ch) | — | 2143 cc | Diesel | 7 versnellingen Automatisch | Euro 6 |
| AMG S 65 V12 (630 CH) AMG SPEEDSHIFT PLUS | 463 kW (630 ch) | 279 g/km | 5980 cc | Benzine | 7 versnellingen Automatisch | Euro 6 |
| AMG S 63 V8 (585 CH) 4MATIC AMG SPEEDSHIFT MCT | 430 kW (585 ch) | 242 g/km | 5461 cc | Benzine | 7 versnellingen Automatisch | Euro 6 |
| S 600 V12 (530 CH) 7G-TRONIC PLUS | 389 kW (530 ch) | 259–268 g/km | 5980 cc | Benzine | 7 versnellingen Automatisch | Euro 6 |
| S 500 V8 (455 CH) 4MATIC 7G-TRONIC PLUS | 334 kW (455 ch) | 211–225 g/km | 4663 cc | Benzine | 7 versnellingen Automatisch | Euro 6 |
| S 500 V8 (455 CH) 7G-TRONIC PLUS | 334 kW (455 ch) | 199–213 g/km | 4663 cc | Benzine | 7 versnellingen Automatisch | Euro 6 |
| S 500 V8 (455 CH) 9G-TRONIC | 334 kW (455 ch) | 192–206 g/km | 4663 cc | Benzine | 9 versnellingen Automatisch | Euro 6 |
| S 500 V8 (455 CH) 4MATIC 9G-TRONIC | 334 kW (455 ch) | 202–216 g/km | 4663 cc | Benzine | 9 versnellingen Automatisch | Euro 6 |
| S 400 (333 CH) HYBRID G-TRONIC | 225 kW (306 ch) | — | 3498 cc | Benzine | 7 versnellingen Automatisch | Euro 6 |
| S 320 V6 (272 CH) 7G-TRONIC PLUS | 200 kW (272 ch) | — | 2996 cc | Benzine | 7 versnellingen Automatisch | — |
| S 500e V6 (442 CH) Plug-in Hybrid 7G-TRONIC PLUS | 325 kW (442 ch) | 65 g/km | 2996 cc | Hybride | 7 versnellingen Automatisch | Euro 6 |