| S 450d (367 CH) EQ Boost 4MATIC 9G-TRONIC | 269 kW (367 ch) | 163–186 g/km | 2989 cc | Diesel | 9 versnellingen Automatisch | Euro 6e |
| S 400d (330 CH) 4MATIC 9G-TRONIC | 242 kW (330 ch) | 175–211 g/km | 2925 cc | Diesel | 9 versnellingen Automatisch | Euro 6D-ISC-FCM |
| S 350d (313 CH) EQ Boost 4MATIC 9G-TRONIC | 230 kW (313 ch) | 161–186 g/km | 2989 cc | Diesel | 9 versnellingen Automatisch | Euro 6e |
| S 350d (313 CH) EQ Boost 9G-TRONIC | 230 kW (313 ch) | 155–180 g/km | 2989 cc | Diesel | 9 versnellingen Automatisch | Euro 6e |
| S 350d (286 CH) 9G-TRONIC | 210 kW (286 ch) | 169–204 g/km | 2925 cc | Diesel | 9 versnellingen Automatisch | Euro 6D-ISC-FCM |
| S 350d (286 CH) 4MATIC 9G-TRONIC | 210 kW (286 ch) | 172–211 g/km | 2925 cc | Diesel | 9 versnellingen Automatisch | Euro 6D-ISC-FCM |
| S 580 V8 (503 CH) EQ Boost 4MATIC 9G-TRONIC | 370 kW (503 ch) | 228–242 g/km | 3982 cc | Benzine | 9 versnellingen Automatisch | Euro 6D-ISC-FCM |
| S 500 (449 CH) EQ Boost 4MATIC 9G-TRONIC | 330 kW (449 ch) | 187–211 g/km | 2999 cc | Benzine | 9 versnellingen Automatisch | Euro 6e |
| S 500 (435 CH) EQ Boost 4MATIC 9G-TRONIC | 319 kW (435 ch) | 181–216 g/km | 2999 cc | Benzine | 9 versnellingen Automatisch | Euro 6D-ISC-FCM |
| S 450 (381 CH) EQ Boost 4MATIC 9G-TRONIC | 280 kW (381 ch) | 184–211 g/km | 2999 cc | Benzine | 9 versnellingen Automatisch | Euro 6e |
| S 450 (367 CH) EQ Boost 4MATIC 9G-TRONIC | 269 kW (367 ch) | 178–215 g/km | 2999 cc | Benzine | 9 versnellingen Automatisch | Euro 6D-ISC-FCM |
| AMG S 63 E PERFORMANCE V8 (802 CH) Plug-in Hybrid 4MATIC+ AMG SPEEDSHIFT MCT 9G | 589 kW (802 ch) | 100 g/km | 3982 cc | Hybride | 9 versnellingen Automatisch | — |
| S 580e (510 CH) Plug-in Hybrid 9G-TRONIC | 375 kW (510 ch) | 14–22 g/km | 2999 cc | Hybride | 9 versnellingen Automatisch | Euro 6D-ISC-FCM |
| S 580e (510 CH) Plug-in Hybrid 4MATIC 9G-TRONIC | 375 kW (510 ch) | 16–23 g/km | 2999 cc | Hybride | 9 versnellingen Automatisch | Euro 6e |
| S 450e (408 CH) Plug-in Hybrid 9G-TRONIC | 300 kW (408 ch) | 14–21 g/km | 2999 cc | Hybride | 9 versnellingen Automatisch | Euro 6e |