| CLS 350 CDI V6 (265 CH) 7G-TRONIC PLUS | 194 kW (265 ch) | 159–160 g/km | 2987 cc | Diesel | 7 versnellingen Automatisch | Euro 5 |
| CLS 350 CDI V6 (265 CH) 4MATIC 7G-TRONIC PLUS | 194 kW (265 ch) | 177–181 g/km | 2987 cc | Diesel | 7 versnellingen Automatisch | Euro 5 |
| CLS 350 BlueTEC V6 (248 CH) 7G-TRONIC PLUS | 182 kW (248 ch) | — | 2987 cc | Diesel | 7 versnellingen Automatisch | Euro 6 |
| CLS 350 BlueTEC V6 (248 CH) 4MATIC G-TRONIC | 182 kW (248 ch) | — | 2987 cc | Diesel | 7 versnellingen Automatisch | Euro 6 |
| CLS 250 CDI (204 CH) 7G-TRONIC PLUS | 150 kW (204 ch) | 134–138 g/km | 2143 cc | Diesel | 7 versnellingen Automatisch | Euro 5 |
| AMG CLS 63 S V8 (585 CH) 4MATIC AMG SPEEDSHIFT MCT | 430 kW (585 ch) | 243 g/km | 5461 cc | Benzine | 7 versnellingen Automatisch | Euro 6 |
| AMG CLS 63 Performance Package V8 (557 CH) AMG SPEEDSHIFT MCT | 409 kW (557 ch) | 231 g/km | 5461 cc | Benzine | 7 versnellingen Automatisch | Euro 5 |
| AMG CLS 63 V8 (557 CH) 4MATIC AMG SPEEDSHIFT MCT | 409 kW (557 ch) | 243 g/km | 5461 cc | Benzine | 7 versnellingen Automatisch | Euro 6 |
| AMG CLS 63 V8 (557 CH) AMG SPEEDSHIFT MCT | 409 kW (557 ch) | 231 g/km | 5461 cc | Benzine | 7 versnellingen Automatisch | Euro 6 |
| AMG CLS 63 V8 (525 CH) AMG SPEEDSHIFT MCT | 386 kW (525 ch) | 231 g/km | 5461 cc | Benzine | 7 versnellingen Automatisch | Euro 5 |
| CLS 500 V8 (408 CH) 7G-TRONIC PLUS | 300 kW (408 ch) | 209 g/km | 4663 cc | Benzine | 7 versnellingen Automatisch | Euro 5 |
| CLS 500 V8 (408 CH) 4MATIC 7G-TRONIC PLUS | 300 kW (408 ch) | 224–226 g/km | 4663 cc | Benzine | 7 versnellingen Automatisch | Euro 5 |
| CLS 550 V8 (402 CH) 7G-TRONIC PLUS | 295 kW (402 ch) | — | 4663 cc | Benzine | 7 versnellingen Automatisch | — |
| CLS 550 V8 (402 CH) 4MATIC 7G-TRONIC PLUS | 295 kW (402 ch) | — | 4663 cc | Benzine | 7 versnellingen Automatisch | — |
| CLS 350 V6 (306 CH) 7G-TRONIC PLUS | 225 kW (306 ch) | 159–164 g/km | 3498 cc | Benzine | 7 versnellingen Automatisch | Euro 5 |