| CLS 350 BlueTEC V6 (258 CH) 9G-TRONIC | 189 kW (258 ch) | 137–142 g/km | 2987 cc | Diesel | 9 versnellingen Automatisch | Euro 6 |
| CLS 350d V6 (258 CH) 4MATIC 9G-TRONIC | 189 kW (258 ch) | 159–166 g/km | 2987 cc | Diesel | 9 versnellingen Automatisch | Euro 6 |
| CLS 350 BlueTEC V6 (252 CH) 4MATIC 7G-TRONIC PLUS | 185 kW (252 ch) | 160–166 g/km | 2987 cc | Diesel | 7 versnellingen Automatisch | Euro 6 |
| CLS 250 BlueTEC (204 CH) 9G-TRONIC | 150 kW (204 ch) | 120–123 g/km | 2143 cc | Diesel | 9 versnellingen Automatisch | Euro 6 |
| CLS 250 BlueTEC (204 CH) 4MATIC 7G-TRONIC PLUS | 150 kW (204 ch) | 140 g/km | 2143 cc | Diesel | 7 versnellingen Automatisch | Euro 6 |
| CLS 220 BlueTEC (170 CH) 9G-TRONIC | 125 kW (170 ch) | 120–123 g/km | 2143 cc | Diesel | 9 versnellingen Automatisch | Euro 6 |
| AMG CLS 63 S V8 (585 CH) AMG SPEEDSHIFT MCT 4MATIC | 430 kW (585 ch) | 239–244 g/km | 5461 cc | Benzine | 7 versnellingen Automatisch | Euro 6 |
| AMG CLS 63 V8 (557 CH) AMG SPEEDSHIFT MCT | 409 kW (557 ch) | 230–234 g/km | 5461 cc | Benzine | 7 versnellingen Automatisch | Euro 6 |
| AMG CLS 63 V8 (557 CH) 4MATIC AMG SPEEDSHIFT MCT | 409 kW (557 ch) | 239–244 g/km | 5461 cc | Benzine | 7 versnellingen Automatisch | Euro 6 |
| CLS 500 V8 (408 CH) 9G-TRONIC | 300 kW (408 ch) | 198–202 g/km | 4663 cc | Benzine | 9 versnellingen Automatisch | Euro 6 |
| CLS 500 V8 (408 CH) 4MATIC 7G-TRONIC PLUS | 300 kW (408 ch) | 224 g/km | 4663 cc | Benzine | 7 versnellingen Automatisch | Euro 6 |
| CLS 500 V8 (408 CH) 4MATIC 9G-TRONIC | 300 kW (408 ch) | 213–219 g/km | 4663 cc | Benzine | 9 versnellingen Automatisch | Euro 6 |
| CLS 550 V8 (402 CH) 9G-TRONIC | 295 kW (402 ch) | — | 4663 cc | Benzine | 9 versnellingen Automatisch | — |
| CLS 550 V8 (402 CH) 4MATIC 9G-TRONIC | 295 kW (402 ch) | — | 4663 cc | Benzine | 9 versnellingen Automatisch | — |
| CLS 400 V6 (333 CH) 7G-TRONIC PLUS | 244 kW (333 ch) | 164–167 g/km | 3498 cc | Benzine | 7 versnellingen Automatisch | Euro 6 |
| CLS 400 V6 (333 CH) 4MATIC 7G-TRONIC PLUS | 244 kW (333 ch) | 179–182 g/km | 3498 cc | Benzine | 7 versnellingen Automatisch | Euro 6 |
| CLS 400 V6 (333 CH) 9G-TRONIC | 244 kW (333 ch) | 166–169 g/km | 3498 cc | Benzine | 9 versnellingen Automatisch | Euro 6 |